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BRAF V600 pathogenic variants were present in 36% of patients and of these, approximately 50% had received previous BRAF inhibitor treatments

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Serum was analyzed with spectrophotometric kits for NEFA, NEFA Fa-115 (Randox, London, UK), -hydroxybutyrate (-HB) by Ranbut RB 1008 (Randox, London, UK), and urea by UREA/BUN Color (Biosystems, Barcelona, Spain) concentrations

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