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General anesthesia or deep sedation GLP-1 therapies, like Saxenda, slow gastric emptying, possibly increasing the risk of residual gastric contents and pulmonary aspiration in patients receiving anesthesia or deep sedation for procedures

Other long-term risks and considerations include: Gallbladder Problems: Some studies and pooled safety analyses indicate an increased risk of gallstones or cholecystitis, particularly with longer treatment durations

Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues with emphasis on nasal absorption

Overall, SGLT2 inhibitors are considered safe and well-tolerated

The pharmacy benefit has advantages (faster dispensing, lower patient cost share) over medical benefit