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doi: 10.1124/pr.116.012484

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Critically, there is one head-to-head study (SURPASS-2) that directly compared the two, plus large independent obesity trials for each

Cancer cells maintain elevated levels of ROS, which activate tumor-promoting pathways involving hypoxia-inducible factor (HIF), phosphoinositide 3-kinase (PI3K), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), and mitogen-activated protein kinase (MAPK) [45]

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