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For type 2 diabetes, NICE guidance (NG28) recommends GLP-1 RAs based on individual factors including comorbidities, prior treatments, and HbA1c targets

The enhanced efficacy of tirzepatide for weight loss compared to semaglutide raises the question of whether similar enhancement exists for alcohol-related outcomes

Step 2: Weekly Weight Loss Injections Quick once-a-week injections with dosing that gradually increases over time to allow your body to comfortably adjust to the medication

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Injection site reactions , if present, typically resolve within days of the last injection

Experimental investigations have demonstrated that cholangiocytes are sensitive to GLP-1 and respond with augmented proliferation, potentially increasing the risk of duct obstruction [47,48]