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Researchers must observe the following precautions at all times

doi: 10.1186/s13046-020-01791-9 65 ChaYJKimESKooJS

The lower concentration of the medication cannot reduce blood sugar spikes, which may lead to hyperglycemia and its complications

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What matters far more than choosing the "perfect" spot is mastering technique, rotating consistently, and avoiding a handful of common mistakes that genuinely do reduce effectiveness

These results were achieved by 36 months, though significant improvements were observed by 6 months (Reich 2016)