It adds psychiatric comorbidities, eating disorder history, and family dynamics as warranting assessment, and says adolescents under active psychiatric care should have input from their mental health provider before anything starts
For example, one study found that Metformin improved live birth rates in women with PCOS who were undergoing in vitro fertilization (IVF)
Additional risks specific to the bodybuilding context include: Cardiovascular strain: Increases in resting heart rate have been observed with GLP-1 receptor agonists as a class (as documented in the Summary of Product Characteristics for licensed agents such as semaglutide and tirzepatide)
Tirzepatide has been shown to support greater average weight loss than placebo, with some participants losing a significant amount of their starting weight
Moreover, the consumption of palatable food increases extracellular dopamine levels in the nucleus accumbens to regulate food-seeking behaviour 6,7
This typically requires BMI of 30 or higher (or 27 with comorbidities), absence of contraindications, willingness to attend regular study visits, and acceptance of randomization (you might receive placebo)
