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Research suggests that combined GIP and GLP-1 activation produces synergistic rather than merely additive effects on appetite and reward processing

"Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and suicidality: A replication study using reports to the World Health Organization pharmacovigilance database (VigiBase)." Journal of Affective Disorders, 2024

These changes are usually related more to weight loss than to a toxic effect of the drug itself