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PMID: 18957686

Existing clinical studies are often small and heterogeneous, limiting conclusions about standardized dosing, long-term safety, and real-world efficacy

Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells

Nat Cell Biol (2014) 16:118091

Daily administration at approximately the same time establishes the consistent exposure that supports tissue repair

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