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It is a complex metabolic disease characterized by insulin resistance, progressive beta-cell dysfunction, chronic inflammation, and an increased risk of cardiovascular disease, kidney disease, neuropathy, retinopathy, and other long-term complications

18, 19 Although the effects of GLP-1 on pancreatic endocrine cells have been well studied, there is little information on the effects of GLP-1R in other pancreatic exocrine tissues that might be involved in inflammatory conditions of the pancreas

If the plasma level is in the high-risk region of the nomogram, the risk of developing hepatotoxicity is 60% or higher, and antidote therapy is warranted

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