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10.1016/j.pediatrneurol.2019.12.001 92
X-ray crystallography and NMR spectroscopy have established that copper coordinates through a 3N1O equatorial square-planar pyramid configuration: the histidine imidazole nitrogen, the glycine -amino nitrogen, and the deprotonated amide nitrogen of the glycine-histidine peptide bond, with additional oxygen coordination from neighboring complex carboxyl groups
Improved well-being is often a result of losing weight, leading to increased energy levels, enhanced self-confidence, and a diminished risk of obesity-related health issues
Common factors include stress, changes in weight, excessive exercise, illness, travel, and hormonal imbalances such as thyroid disorders or polycystic ovary syndrome (PCOS)
Patients with chronic pancreatitis or other enzyme deficits are at increased risk of B12 deficiency even when the rest of the absorption pathway is intact
