Several other trials are assessing the safety and efficacy of tirzepatide in improving different cardiometabolic complications such as OSA, MASH and heart failure with preserved ejection fraction (HFpEF) (NCT05412004, NCT04166773, NCT 04847557) [16]
J Diabetes Investig 1:823 Samms RJ, Coghlan MP, Sloop KW (2020) How may gip enhance the therapeutic efficacy of GLP-1
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In the next section, we will focus on the diverse roles of GLP-1 in depression ( Table 1 )
It is well established that -cells are more vulnerable to ROS due to their low antioxidant capacity and poor ability to repair oxidatively damaged DNA [22,31]