Further investigation is critical to understand the health implications of specific nutritional and microbiome interventions on endogenous GLP-1 secretion
Not daily weight the weekly average
Drugs that raise blood glucose (such as corticosteroids, certain antipsychotics, or thiazide diuretics) may counteract glycaemic benefits
Recently, to ensure the safety of GLP-1 RA on sarcopenia, a clinical randomized multicenter trial of bimagrumab, an antibody blockade of activin type II receptor inhibitor, alone or in addition to subcutaneous semaglutide is now ongoing (NCT05616013) [113]
Due to the promotive effect of GLP-1R agonism on -cells proliferation and survival, concerns of tumorigenesis, especially pancreatic cancers, have been raised about incretin-based therapies (89)
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