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The peptide works through non-hormonal mechanisms, does not suppress natural production of any substance, and shows no rebound effects upon discontinuation

Moreover, in mice, the administration of TZP showed to inhibit gastro-enteric delay ( Experimental data on animal models have suggested that GIP suppresses peripheral arterial remodeling, thus showing an anti-atherosclerotic activity, by acting on receptors in the heart and vessels (68) and kidneys

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