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As DNA damage accumulates with age and exercise, PARP activity increases which can deplete NAD+ rapidly

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Bilbo SD, Nevison CD, Parker W

Major drug Interactions: The pressor effect of sympathomimetic pressor amines is markedly potentiated in patients receiving monoamine oxidase inhibitors (MAOIs) References: Alhashemi JA (2002): Reduction of vasopressor requirement by hydrocortisone administration in a patient with cerebral vasospasm

Metformin is an old drug with multiple beneficial metabolic health effects beyond glycemic control

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