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Dose reduction is recommended with renal impairment, and higher-than-recommended exposure may increase the risk of CNS effects and QT prolongation

[PubMed: 24590381] 317

Pregnant or nursing women and individuals with health conditions or on medications should be cautious before using the supplement

Additionally, MOTS-c has shown potential in combating age-related decline and metabolic disorders such as obesity and type 2 diabetes

in vivo, hypercoagulation decreased upon LC treatment (ElGendy 2014): hypothesized

Glutathione reductase activity regenerates GSH from GSSG, thus helps to maintain a reduced microenvironment and ensures substrate availability for glutathione peroxidase