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We validated previously reported pharmacokinetic parameters [48] in diabetic rats (i.e., elimination half-life, volume of distribution, bioavailability, and absorption rate) by conducting a 24-hour pharmacokinetic (PK) study following intravenous (IV) administration of a 20 g dose of Sema in a saline vehicle ( Table S1 )

However, in the CA1 hippocampal subregion the current is normally outward (344), and thus increased expression of 42 GABA receptors paradoxically results in ALLO attenuating rather than enhancing inhibition

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doi:10.1111/j.1600-0560.1991.tb01542.x

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