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Since treatment with exendin-4 only modestly lowered cholesterol level and affected lipoprotein profile of the mice, anti-atherogenic effect was independent of modulation of plasma lipid levels and dependent on anti-inflammatory response

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It primarily activates the MC3R and MC4R subtypes of the melanocortin receptor family, making it a valuable compound in studies of neuropeptide signaling, central nervous system modulation, and GPCR-targeted pharmacology

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When combined with regular diet and exercise, GLP-2 promotes weight loss and a healthier, more active lifestyle