Mechanistically, ferroptosis is distinct from other forms of programmed cell death: unlike apoptosis or pyroptosis, it does not depend on caspase activation, nor is it primarily driven by ATP depletion or mitochondrial ROS generation, which are central to necroptosis
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27 , have recently reported that cancer cell lines subject to hypoxia are more invasive, have increased migratory ability and an epithelial-mesenchymal transition (EMT) phenotype 27
These results agree with those obtained by Gendelman and Roth (2012a, b) 12,66
So it's not, like a only one direction, you there is a risk-benefit, and so, you know