While the company did not publicly disclose specific reasons for discontinuation, the lack of statistically significant dose-response at Week 8 in the Phase 2b trial, likely contributed to the decision not to pursue further development in UC
Currently, it appears that TB4 and TB-500 are best suited for adults with: Troublesome injuries or wounds (including those that are slow to heal) Inflammation Chronic pain due to inflammation Health issues involving the heart, liver, or eyes But its essential to remember that the research on these peptides is still in the early stages, and there have been only a handful of human trials
Guidelines by an ad hoc European committee
Recommended Dosage of Glutathione for Skin Support Based on available clinical studies and standard nutritional practice, here are the dosage guidelines: General skin support and antioxidant defence: 250mg per day Targeted skin radiance support: 500mg per day Upper range (under practitioner guidance): 500-1000mg per day How to Take It Take on an empty stomach ideally 30 minutes before breakfast or 2 hours after dinner Pair with Vitamin C (500-1000mg) to support glutathione recycling Stay consistent daily supplementation is important for building and maintaining levels Drink adequate water throughout the day Is It Safe for Long-Term Use
FDA concerns
Higher doses up to 50 micrograms/kg are sometimes used for severe injuries
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