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In an in vitro H9c2 cell model subjected to hypoxia/reoxygenation, AS-IV upregulated the expression of GATA-binding protein 4 (GATA-4), Bcl-2, and P62, while downregulating apoptosis and autophagy-associated genes such as PARP, caspase-3, and Beclin-1

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A diet high in iron leads to reduced GSH levels and increased lipid peroxidation, causing significant heart damage and the development of hypertrophic cardiomyopathy

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