Critically, this redox adaptation is a key mechanism of resistance to radiotherapy and many chemotherapeutic agents, such as cisplatin and doxorubicin, which depend on generating oxidative damage to exert their cytotoxic effects [33]
doi: 10.3109/09513590.2014.943725 134 OrioFPalombaS
When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted
That's an important limitation
Once those subcutaneous fat compartments fill up, wherever they may be, fat will bury itself deeper in the body in the midsection, around your organs
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