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Epilepsy in Leigh syndrome with mitochondrial DNA mutations

MC4R agonism reduces ghrelin signalling and delays the gastric emptying rate, creating early satiety that lasts 48 hours

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Reference for approved GHRH-analog regulatory status

(or 0.16 g/mL per-oral) given concurrently with 12.5 mg/kg/day diclofenac in Wistar rats directionally counteracted diclofenac-induced gastric, intestinal, and hepatic lesions and reduced elevations in bilirubin, AST, and ALT though the abstract does not report numeric magnitudes or p-values