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If liver fat reduction is a key objective, retatrutide offers substantially greater hepatic fat clearance than tirzepatide, as discussed above
Alternatively, others like dulaglutide (Trulicity) are administered once a week
Their mechanism gives them two major downstream effects of interest: improved glycemic control and weight reduction (due to appetite reduction + slower gastric emptying) plus other possible metabolic benefits
Human trials are limited and not yet conclusive
Most side effects hit during the first 1-2 weeks at each new dose level
Diabetes Res Clin Pract.1994 Aug;25(1):43-9
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