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Clinical trials such as SURMOUNT-1 have demonstrated average weight loss of 15-21% of body weight over 72 weeks (depending on dose), with much of this effect attributed to reduced caloric intake

In particular, adequate intake of both folate and vitamin B 12 is important in maintaining the integrity of the myelin sheath, and thiamin is needed for maintenance of the nerves membrane potential and for proper nerve conductance (3)

In SURMOUNT-5, gastrointestinal adverse events were common in both groups, which is expected for this drug class

Most before-and-after claims are unverified

Each location offers different advantages: your abdomen typically has more fatty tissue for consistent needle placement, your thigh is easier to reach and visualize, and your upper arm works well if you have someone assisting you

Currently available studies have not explained this result