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Apart from their role in insulin secretion, GLP-1RAs delay gastric emptying, stimulate the appetite centers in the brain to induce early satiety, and consequently reduce food consumption [13, 26, 56]

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Metreleptin: first global approval

J Inflamm

The overlap between the dimer interface and the N domain binding site suggests competition between dimerisation and SMAX1 binding, potentially reducing the number of SMAX1-containing ASK1MAX2(HTL7) particles in vitro