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Although tiny, neutral molecules may permeate lipid bilayers, RNA therapeutics, such as siRNAs, ASOs, and CRISPR components, are substantial, charged macromolecules that cannot traverse these membranes independently and are instead internalized by endocytosis, subsequently being sequestered within endosomes
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N., Bu, H
10.1007/s11684-019-0724-6 Front Med
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