Gonadotrophins inhibit the expression of insulinlike growth factor binding proteinrelated protein2 mRNA in cultured human granulosaluteal cells
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Under sustained reductions in nutrient inflow, metabolic reserve may narrow as reduced substrate availability limits mitochondrial redox regeneration and constrains the capacity to match oxidative flux with regenerative turnover
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(1) Adolescence (1218 years): high sensitivity to high-sugar diets Although human studies investigating the gut microbiome in adolescents remain limited, the ongoing development of the gut-brain axis and the adolescent brain suggests that this population may be particularly susceptible to diet-induced depressive symptoms (320), The impact of high-sugar diets on metabolic and intestinal health In male C57BL/6J mice, consumption of a high-glucose diet (HGD) over a 12-week period induces hyperglycemia, glucose intolerance, dyslipidemia, and increased adipose deposition