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Dysbiosis of the gut microbiota can lead to hyperactivity of the HPA axis, resulting in elevated levels of ACTH and CORT, as well as reduced BDNF

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Oct 2016;30(10):1665-1671

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These results are interesting given that, in cats, pre-weight-loss adiponectin concentrations are negatively correlated with the amount of lean tissue lost during weight reduction 49 , although this has not been seen in dogs

Dietary Adjustments: Patients may benefit from dietary modifications, such as eating smaller, more frequent meals to avoid overwhelming the digestive system