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The split dosing maintains more consistent tissue concentrations given peptide half-lives

Isotretinoin is a common medication for the treatment of acne but it does have some side effects

Photomicrographs were taken using a transmitted light microscope (Olympus Vanox, Olympus, Tokyo, Japan)

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Dose-dependent fat loss was also observed, with statistically significant weight loss seen with the three highest doses compared to the placebo

The FDA has explicitly warned against these, stating safety concerns and lack of clinical evidence