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Additionally, angiotensin II contributes to endothelial dysfunction by inducing expression of vascular endothelial growth factor and increasing reactive oxygen species, which reduce the bioavailability of vasodilators (such as nitrous oxide) responsible for maintaining normal glomerular vascular tone [14]

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It can be administered intranasally, but the gold standard for efficacy is injectable. The same is true for GHKCU, a collagen-boosting, inflammation-reducing peptide that, says Kahn, is getting a lot of attention in skin-care circles