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Beyond antimicrobial effects, certain peptides contribute to the integrity of the gut barrier by reducing intestinal permeability, which prevents the translocation of bacterial products that can trigger systemic inflammation

It should be noted that physiologic GLP-1R agonism in the periphery mediates food intake reduction via vagal afferent signaling as rats with a surgical subdiaphragmatic vagal deafferentation (SDA) exhibit a more mild food intake suppression in response to acute administration of GLP-1 analogues than sham operated animals (80, 81)

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