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If you have been diagnosed with autoimmune thyroid disease (Hashimoto's or Graves' disease), you can still use GLP-1 therapy, but ongoing monitoring of thyroid antibodies and hormone levels is recommended

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Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, and it requires caution in those with severe gallbladder disease or uncontrolled diabetes

Moderate-to-vigorous physical activity also dropped, from 28 minutes a day to 22 minutes a day, according to a release from the Endocrine Society

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Excess weight is often associated with higher levels of LDL cholesterol and triglycerides