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In adipose tissue, GLP-1 receptors are directly expressed and activation impacts apoptosis and preadipocyte proliferation, as well as fat deposition through regulation of lipolysis, fatty acid oxidation, and adipocyte differentiation

1,5 Polyphenol-rich foods Natural phenolic compounds are increasingly recognized as modulators of incretin pathways

GLP-1 medications support weight loss by reducing cravings and quieting food noise

They improve insulin sensitivity in peripheral tissues

Key highlights Retatrutide is a peptide weight loss medication with triple agonism at GLP-1, GIP, and glucagon receptors