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Dry eye disease Dry Eye Disease (DED) is a multifactorial condition of the ocular surface characterized by a loss of tear film homeostasis, with a particularly high prevalence among individuals with diabetes (Diabetic Dry Eye Syndrome, DDES) [118,119,120,121]

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This may offer therapeutic applications in injury recovery and post-surgery settings

A 1:1 propensity matching was also employed to account for confounders, including demographics, comorbidities, insulin use, and use of other second-line diabetic agents

Zinc also inhibits the excessive release of histamine from mast cells, providing crucial support for patients managing comorbid Mast Cell Activation Syndrome (MCAS) alongside their dysautonomia