Borg CM, le Roux CW, Ghatei MA, Bloom SR, Patel AG, Aylwin SJ
Gastrointestinal effects predominate: | Side Effect | Orforglipron | Oral Semaglutide | Tirzepatide | |-------------|-------------|-----------------|-------------| | **Nausea** | 22-28% | 24-28% | 24-31% | | **Vomiting** | 8-12% | 10-14% | 9-13% | | **Diarrhea** | 14-18% | 12-16% | 14-21% | | **Constipation** | 10-14% | 8-12% | 11-15% | | **Dyspepsia** | 6-9% | 8-11% | 5-8% | | **Discontinuation due to AEs** | ~6-8% | ~7-9% | ~4-7% | A notable difference: oral semaglutide has higher rates of upper GI symptoms (reflux, dyspepsia) because the SNAC formulation makes direct contact with gastric mucosa
Due to increased demand for medications like Ozempic, providers in general practice settings have become increasingly familiar with how to prescribe these medications
Williamson JR, Arrigoni ME, Martelli E (1992)
Maintaining healthy weight can drastically improve your overall health and well-being and reduce your risk of chronic health conditions like heart disease and type-2 diabetes
Chacun de ces mdicaments doit tre inject une fois par semaine dans le ventre, la cuisse ou le haut du bras
