The American Diabetes Association (ADA) recommends [archived link] GLP-1 RAs as first-choice Type 2 diabetes medication options in many cases
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412 Notably, GLP-1RAs, including exendin-4, have been shown to attenuate microglial activation, resulting in a reduction in the expression of proinflammatory cytokines such as TNF- and IL-1
Nadler adds