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There have been rare reports of more severe reactions to prolotherapy, such as ligament rupture or spinal headaches, when injections were done in delicate areas or not using image guidance

Spreafico A, Frediani B, Capperucci C, Leonini A, Gambera D, Ferrata P, et al

PMID 10047539

Manning, Sport Physician MD CCFP(SEM) DipSportMed

The Science of Cellular Defense: How Liposomal Glutathione Will Transform Anti-Aging by 2025 Liposomal Glutathione for Anti-Aging is quickly becoming one of the most exciting breakthroughs in skincare and longevity and its easy to see why

That means nasal dosing often needs to consider a slightly higher dose (or more frequent spritz) to match systemic exposure from injection