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Similarly, metformin administration commonly induces gastrointestinal disturbances, manifesting as diarrhea, abdominal distension, and nausea 12 , with potentially severe complications including lactic acidosis in rare instances 13

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In a similar study among Chinese neonates, this test showed a sensitivity of almost 100% in deficient cases involving both males and females with residual enzyme activity below 60% (74)

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