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It's also about how long your protocol needs to run before results become visible
The access to the primary care and linked datasets requires approval but can be requested via applications to the Clinical Practice Research Datalink Research Data ( Statistical codes are available at: ( Abbreviations SGLT2: Sodium-glucose cotransporter 2 GLP1: Glucagon-like peptide-1 DPP4: Dipeptidyl peptidase-4 CARMELINA: The CArdiovascular and Renal Microvascular outcomE study with LINAgliptin CAROLINA: CARdiovascular Outcome study of LINAgliptin versus glimepiride in patients with type 2 diabetes BMI: Body mass index eGFR: Estimated glomerular filtration rate HbA1c: Hemoglobin A1c VD: Vascular dementia AD: Alzheimers disease HR: Hazard ratio IRD: Incidence rate difference CI: Confidence interval PPV: Positive predictive value CPRD: Clinical Practice Research Datalink ONS: Office for National Statistics HES APC: Hospital Episode Statistics Admitted Patient Care OPCS: The UK Office of Population, Census and Surveys classification ICD-10: International Statistical Classification of Diseases version 10 References Gudala K, Bansal D, Schifano F, Bhansali A
Both sit at the preclinical tier mechanistically plausible, supported by cell-culture and animal studies, but not confirmed by controlled human trials
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Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity
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