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Pharmacological activation of Nrf2 enhances the expression of cytoprotective genes, conferring resistance against oxidative injury and fibrogenesis in DKD models (242)

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reported outcomes are more plausibly indirect via recovery, routine adherence, and activity changes

These improvements were also linked to enhanced cerebrovascular function

Additionally, injectable forms carry higher risks of adverse effects compared to oral preparations, making them a less favorable option from both efficacy and safety perspectives