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A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data

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These personalized schedules account for individual response patterns and goals, optimizing the timing of different compounds throughout the year

Perhaps most notably, the researchers observed no adverse effects even at high doses