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Notably, CYP27B1 is also expressed in extra-renal tissues such as the placenta and prostate, where it facilitates local synthesis of 1,25(OH)D to modulate cellular functions via paracrine or autocrine signaling [96, 99]

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Why GLP-1 Medications Are Gaining Attention Why GLP-1 Medications Are Gaining Attention GLP-1 receptor agonists were first used for type 2 diabetes, but quickly proved to have far broader effects

10.3389/fimmu.2023.1192506 84 LiL.CuiN.HaoT.ZouJ.JiaoW.YiK.et al (2021)

However, peripheral IGF-1 levels do not always translate directly to brain outcomes