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The commonly referenced therapeutic range of 0.25-0.5 mg daily (250-500 mcg) extrapolates from the effective rat dose of approximately 10 mcg/kg body weight

Jumping to the full dose immediately would produce severe nausea and vomiting in most people

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Oral NAD+ supplements usually contain components that your body turns into NAD+

The total dosages should not exceed 3 mg/kg (1.4 mg/lb) for induction of intravenous regional anesthesia in children