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This observation is not surprising considering the loss of function of pVHL in a number of renal cancers leading to stabilization of HIF- and subsequent pseudohypoxic possibly resulting in an increased activity of GCLC and GCLM

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10.1016/j.neuron.2014.11.018 275 LiangS.ZhaoL.NiP.WangQ.GuoW.XuY.et al

Simply use a hydrating moisturizer that contains Hyaluronic Acid or Ceramides if this happens

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