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A vial isnt just 5mg or 10mg in isolation that mass has to be matched against the intended use volume, and the same mass can support meaningfully different concentrations depending on how much diluent is introduced

"GLP-1 Receptor Agonist Use and Risk of Suicide Death." JAMA Internal Medicine, 3 Sept

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PNPO mutations are treated with high doses of P5P (active form), thus providing the active form of B6 without the need for conversion

Table 2 Pooled estimation and epidemiological credibility assessment of the included meta-analyses on the safety of GLP-1 RAs in MASLD