For example, Ozempic (semaglutide) retains the GLP-1(737) scaffold but incorporates an Ala8-aminoisobutyric acid (Aib) substitution to block DPP-4 cleavage, a Lys34Arg substitution, and an 18-carbon fatty diacid attached at Lys26 to confer albumin binding and slow clearance
GLP-1 stands for glucagon-like peptide-1, a natural hormone that helps regulate blood sugar, appetite, and digestion
Melanin index For objective evaluation of skin color, melanin index as determined by Mexameter (Courage-Khazaka Electronic, Koln, Germany) was used as the primary outcome
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however, commercially viable product titres have not yet been reached, partly due to issues arising from the late steps of the biosynthetic pathway 6,7
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