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Semaglutide use is increasingly associated with gastroparesis, a condition marked by delayed gastric emptying, causing nausea, vomiting, abdominal pain, bloating, satiety, acid reflux, and blood sugar fluctuations

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In hypoxic HUVECs, eNOS Ser1177 phosphorylation was shown to be reduced, whereas Thr495 phosphorylation was increased, resulting in altered eNOS activity and reduced NO production [148]