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The full-length three-dimensional structure of LONP1 was first resolved in 2016 by the Kereche team using cryo-electron microscopy, revealing its unique hexameric architecture: the P-domains form a bowl-shaped cavity, topped by the AAA+ modules, while the N-terminal domains create a narrow channel [21] (Fig

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In a third study estimating the prevalence of GLP-1 based therapy discontinuation among new users with T2DM or obesity, patients who had new GI adverse events at follow-up were reported to have a significantly higher odds of treatment discontinuation at 12 months compared with patients who did not have a new GI adverse event (odds ratio: 1.04