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10.4093/dmj.2011.35.5.444 87 JoanneY.SophieR.RyoK.EcosseL

NMP, N-methylprotoporphyrine IX

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Second, like all proteins neurotrophic factors are susceptible to degradation by proteases and hence require chronic dosing methods

Turton MD, OShea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, et al

Notably, the expression of inducible costimulatory molecules (ICOS) on CD4 + T cells is significantly increased in the inflammatory mucosa of IBD patients, and this overexpression promotes the production of inflammatory cytokines such as IL-5 in UC and IFN- in CD, suggesting that ICOS may serve as a potential therapeutic target for IBD [40]