Specific examples of methylation in detoxification: Arsenic detoxification requires sequential methylation: arsenite to monomethylarsonic acid to dimethylarsinic acid (the excretable form), catalyzed by arsenic methyltransferase (AS3MT) using SAM-e R Mercury undergoes methylation by gut bacteria, converting inorganic mercury to more toxic methylmercury (this is detrimental methylation, not detoxification) R COMT methylation of 4-hydroxy catechol estrogens prevents them from forming reactive quinones that generate ROS and DNA damage R 6
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70 in native IGF-1) These modifications make LR3 resistant to insulin-like growth factor binding proteins (IGFBPs) , allowing it to remain biologically active for up to 2030 hours in circulation
1 It can also be found in small amounts in certain foods like beef, fish, and chicken
2,13 Liver biopsy is the only test that distinguishes hepatic steatosis from nonalcoholic steatohepatitis, but its routine use is controversial in persons with nonalcoholic fatty liver disease
In principle, this may be analogous to the demonstrated BPC 157NO-system relations in many models and species (see Sikiric et al., 2014